The HIVE Collaboration Component (CC) developed and provided robust collaboration strategies and resources to catalyze HuBMAP toward the goal of mapping the human body at high resolution. The CC cultivated a climate and culture to inspire collaboration, learn from the community, and be agile in experimenting with, adopting, and contributing to best practices. They built a sustainable, functional, and coherent team with a shared sense of purpose and community of practice via a climate of innovation and excitement around the HuBMAP mission. To align and enhance communication, the CC developed a collaboration portal to enable virtual meetings and a website to handle knowledge management. Internal and external face-to-face meetings were convened and expertly facilitated. Cross- component standing committees were supported by the CC, and liaised with broader HuBMAP governance. The result was the rapid development and deployment of flexible adaptive teams to execute the needed steps to address issues in an agile and iterative fashion. The challenges inherent in team science were mitigated through the extensive experience of the PI team, the support from their institutional and organizational structures, and the knowledge and guidance of expert facilitators.