Transformative Technology Development

Spatial in situ mapping of RNA-chromatin interactions at transcriptome-and-genome scale in human tissues

This group aims to simultaneously improve the state-of-art spatial resolution, dynamic range of RNA quantification, and applicable dimensions of human tissue by one to several orders of magnitude. This breakthrough will deliver to users extremely high-resolution, high-density, high-fidelity and reproducible spatial mapping slides (HiFi slides) for spatial transcriptome analysis or spatial mapping of modified- or interacting- nucleic acids. The team will leverage HiFi slides to provide spatial transcriptome of human placenta and brain.

Fast Facts
Project title: Spatial in situ mapping of RNA-chromatin interactions at transcriptome-and-genome scale in human tissues
PI: Sheng Zhong
Project Manager: Tianyang Xu
Grant number: 4UH3CA256960-03
Learn more: Visit the lab website


 

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