This group aims to simultaneously improve the state-of-art spatial resolution, dynamic range of RNA quantification, and applicable dimensions of human tissue by one to several orders of magnitude. This breakthrough will deliver to users extremely high-resolution, high-density, high-fidelity and reproducible spatial mapping slides (HiFi slides) for spatial transcriptome analysis or spatial mapping of modified- or interacting- nucleic acids. The team will leverage HiFi slides to provide spatial transcriptome of human placenta and brain.