Requests for Application
New Investigator Projects on 4D Nucleome Organization and Function in Human Health and Disease
You may be interested in a new NIH Common Fund Request for Applications (RFA):
, “New Investigator Projects on 4DN Organization and Function in Human Health and Disease (U01 Clinical Trial Not Allowed).” The purpose of this RFA is to support projects from scientists who are in the early stages of establishing an independent research career that apply new or existing tools to monitor and/or manipulate the 4D nucleome (4DN) in the context of human health and disease. Any human disease or biological process relevant to NIH’s mission may be proposed including environmental exposures or studies across development or lifespan.
This initiative is part of Phase 2 of the
program. Programs supported by the NIH Common Fund address emerging scientific opportunities and pressing challenges in biomedical research that no single NIH Institute or Center can address on its own, but are of high priority for the NIH as a whole. Common Fund programs are intended to change paradigms, develop innovative tools and technologies, and/or provide fundamental foundations for research that can be used by the broad biomedical research community. The goal of the 4DN program is to study the three-dimensional organization of the nucleus in space and time. Phase 2 of the 4DN program will focus on the roles of chromosome organization in health and disease, chromatin dynamics and function, and the development of new approaches to modeling and visualizing the spatial and temporal organization of the nucleus.
Important Funding Opportunity Information
Application receipt date: March 2, 2020
Letter of Intent due date: 30 days prior to application due date.
Budget: Application budgets may not exceed $400,000 in direct costs in any one year.
Award Project Period: The maximum project period is 5 years.
Eligibility: Eligible PIs for RFA-RM-20-006 must be an investigator(s) who has not yet competed successfully for a substantial, competing NIH independent research award. Interested PI(s) who are not eligible to this FOA should instead apply to the companion Funding Opportunity Announcement,
There will be a pre-application webinar for potential 4DN Phase 2 applicants on January 21, 2020 at 1:00 pm Eastern Time.
The webinar is expected to last for 2 hours.
and follow the WebEx instructions:
: 1-650-479-3207 Call-in toll number (US/Canada)
: 733 412 130
Participation in the webinar, although encouraged, is optional and is not required for the submission of an application. Following the Webinar, the slides will be posted
Potential applicants to RFA-RM-20-006 are
encouraged to reach out to the scientific contact, Lisa Postow (
), to discuss the alignment of their proposed work with the goals of this RFA.
Kristin Burnum-Johnson from Julia Laskin’s lab published
in Nature. There is also an article written about the work in the PNNL newsletter, found
Upcoming Meetings & Events
call will be held Wednesday, January 15 @ 10AM ET.
Tissue, Technology, and Data Collection
working group meeting will take place Tuesday, January 21 @ 2PM ET.
Save the Date
Annual HuBMAP Meeting
will take place May 18 - 20, 2020 in Bethesda, MD. Agenda and venue TBD.
Doctor: "Your DNA is backwards."
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