(RFAs)HeartShare: Next-Generation Phenomics to Define Heart Failure Subtypes and Treatment Targets
Clinical Centers
This funding opportunity announcement (FOA) invites applicants to participate in a new NHLBI phenomics program, HeartShare: Next Generation Phenomics to Define Heart Failure Subtypes and Treatment Targets (hereafter referred to as “HeartShare”). The goal of this program is to conduct large-scale analysis of phenotypic data, images, and omics from patients with heart failure with preserved ejection fraction (HFpEF) in order to characterize mechanisms of disease and identify therapeutic targets.
This FOA solicits applications for Clinical Centers (CCs) that will recruit and retain heart failure patients, comparators, and controls. CCs will participate in all aspects of planning and conducting a deep phenotyping protocol for HFpEF patients, as well as interpretation and translation of results. A companion FOA (RFA-HL-21-016) will support a Data Translation Center for overall coordination of the HeartShare program.
This funding opportunity announcement (FOA) invites applicants to participate in a new NHLBI phenomics program, HeartShare: Next Generation Phenomics to Define Heart Failure Subtypes and Treatment Targets (hereafter referred to as “HeartShare”). The goal of this program is to conduct large-scale analysis of phenotypic data, images, and omics from patients with heart failure with preserved ejection fraction (HFpEF) in order to characterize mechanisms of disease and identify therapeutic targets.
This FOA solicits applications for a Data Translation Center (DTC) that will be responsible for overall project coordination, support development of a new cohort of HFpEF patients, and curate and analyze existing data from NIH cohorts and trials. A companion FOA (RFA-HL-21-015) will support the Clinical Centers.
Reminder: HIVE Quarterly Progress Reports Due October 1
Environmental Molecular Sciences Laboratory (EMSL) "Visualizing the Proteome" Meeting
EMSL Integration 2020—Visualizing the Proteome will be held virtually October 5-8, by Pacific Northwest National Laboratory. There is no fee to attend, but registration is required.
This engaging meeting will encompass the following topics:
Pushing the frontier of structural biology
Understanding subcellular compartmentalization and ultrastructure
Annotating protein function and modifications via native and top-down proteomics
Revealing cellular complexity and dynamics with single to few-cell proteomics
Advancing cellular models and protein design with high-performance computing
Please register by October 5. Link to agenda here. Link to registration here.
Dear Dena
I was perusing the data on our portal and realized there are some really cool pictures on there!
We should show more of these to the world!
Sincerely,
Why Hide Our Fluorescent Light Under a Bushel?
Dear That Is Downright Enlightening!,
I’m so glad you said something because it occurred to me that we need to show off the cool images from HuBMAP, and thus, I present to you “The Image of the Week”.
What is “The Image of the Week” you ask? That is where you choose an image that your group is very proud of, write up an accompanying caption for it, and send it to me, your friendly neighborhood advice columnist.
I will choose one to be the Image of the Week, and include it in the Happenings, and then we will add it to our Twitter feed, and the NIH’s social media accounts to get as many people to see your image as possible.
We are starting with this seqFISH image (below) of the heart from the CalTech TMC, which was posted on the NIH’s Instagram account and Twitter feed for World Heart Day.
Please send me your images by CoB Friday of each week to be included in the Happenings.
A position is available within the NCI Single Cell Analysis Facility that provides dedicated support to the NCI Center for Cancer Research. The person in this position would work closely with the rest of the Single Cell Analysis Facility team to support state-of-the-art single cell methods such single cell gene expression profiling, vdj sequencing, epigenomic profiling, and proteogenomic and multimodal analyses, as well as spatial expression profiling and other emerging methods. This work is in support of both basic science and translational research projects.
More information about the roles and expected qualifications can be found at this link on the Leidos Biomedical Research Inc career website. Leidos operates the Frederick National Laboratory for Cancer Research (a FFRDC) through a long-standing contract with NCI.
Please contact Kimia Dadkhah (kimia.dadkhah@nih.gov) or Michael Kelly (michael.kelly3@nih.gov) about this position.
Developmental Genotype-Tissue Expression RFA
The National Human Genome Research Institute (NHGRI) and the Eunice Kennedy Shriver National Institute for Child Health and Human Development (NICHD) are co-collaborating on a new initiative, developmental Genotype-Tissue Expression (dGTEx), to catalog and analyze transcriptional profiles from a wide variety of tissues from the pediatric period, including neonates through adolescents, in a post-mortem setting.
UC San Diego Institute for Genomic Medicine Symposium on Spatial Omics
The UC San Diego Institute for Genomic Medicine is holding a virtual symposium on Monday, October 26, 2020. This meeting calls scientists from across the United States to come together and contribute their cutting-edge ideas on "Spatial Omics.” As a platform for researchers to discuss the latest advancements on spatial gene expression, this meeting strives to glean novel insights into the role cell-type specific regulatory mechanisms play in complex traits. It is in conjunction with the virtual American Society of Human Genetics meeting occurring on October 27th through October 30th, 2020.
HuBMAP PIs Long Cai and Katy Börner will be presenting.
The course opened Tuesday, September 1, 2020 in parallel with the 1st HuBMAP Portal Release. It will welcome students continuously until the 2nd HuBMAP Portal Release begin of January 2021.
The course aims to provide you with:
Theoretical and practical understanding of different single-cell tissue analysis techniques.
Expertise in single-cell data harmonization used to federate data from different individuals analyzed using different technologies in diverse labs.
Hands-on skills in the design and usage of semantic ontologies that describe human anatomy, cell types, and biomarkers (e.g., marker genes or proteins).
Knowledge on the design and usage of a semantically annotated three-dimensional reference system for the healthy human body.
An understanding of how the HuBMAP reference atlas might be used to understand human health but also to diagnose and treat disease.
Most people know that SCUBA is an acronym, but TUBA is also an acronym...
Terrible Underwater Breathing Apparatus
HIVE Infrastructure
Developers in need of HIVE infrastructure may request access through the PSC web form, foundhere.
Instructions for using HIVE infrastructure can now be found in the "Quick Links" section of the Collaboration Portal. A direct link to this documentation can be found here. Please report any issues or direct any questions to help@hubmapconsortium.org.
Content Suggestions
The IEC is seeking to collect information of general interest from individual members and groups to share with the rest of the Consortium. Please submit content suggestions by emailing admin@hubmapconsortium.org.
Past Newsletters are available on the Collaboration Portal.
For comments, suggestions about how to improve the HuBMAP Happenings, or questions about the consortium, please contact: help@hubmapconsortium.org
