Impact of Genomic Variation on Function (IGVF) Consortium
NHGRI (National Human Genome Research Institute) encourages applicants for a new program—the Impact of Genomic Variation on Function (IGVF) Consortium—to develop a framework for systematically understanding the effects of genomic variation on genome function and how these effects shape phenotypes.
Investigators with diverse expertise in genetics, genomics, and data science are needed and will be supported through five (5)Funding Opportunity Announcements with applications due on November 4, 2020.
IGVF will be organized as a research consortium that brings investigators together in a highly collaborative effort to examine how genomes function, how genome function shapes phenotypes, and how these processes are influenced by genomic variation. The program will utilize emerging experimental and computational genomic approaches to build a catalog of the impact of genomic variants on genome function and phenotypes.
NHGRI strongly encourages all investigators with innovative ideas aligned with IGVF goals to submit applications, especially investigators from demographic groups or institutions generally underrepresented in genomic science, new investigators, experienced investigators who are new to genomic science, and investigators who have not previously participated in a NHGRI-consortium or program.
Informational webinars will be presented September 3, 2020 and September 9, 2020. Please see NOT-HG-20-055 for details.
For more information, please review the IGVF Funding Opportunity Announcements (FOAs) below, visit the IGVF website, and reach out to the Scientific Contacts with any questions:
RFA-HG-20-043; Systematic Characterization of Genomic Variation on Genome Function and Phenotype (UM1 Clinical Trial Not Allowed). Scientific Contact: Mike Pazin, Ph.D., michael.pazin@nih.gov.
RFA-HG-20-044; Defining Genomic Influence on Gene Network Regulation (U01 Clinical Trial Not Allowed). Scientific Contact: Daniel Gilchrist, Ph.D., daniel.gilchrist@nih.gov.
RFA-HG-20-045; Single-cell Profiling of Regulatory Element and Gene Activity in Relationship to Genome Function (UM1 Clinical Trial Not Allowed). Scientific Contact: Stephanie A. Morris, Ph.D., morriss2@mail.nih.gov.
RFA-HG-20-046; Genomic Variation and Function Data and Administrative Coordinating Center (U24 Clinical Trial Not Allowed). Scientific Contact: Stephanie A. Morris, Ph.D., morriss2@mail.nih.gov.
RFA-HG-20-047; Developing Predictive Models of the Impact of Genomic Variation on Function (U01 Clinical Trial Not Allowed). Scientific Contact: Daniel Gilchrist, Ph.D., daniel.gilchrist@nih.gov.
Cancer Moonshot: Data Visualization and Cancer Research: A Series of Virtual Events
Data are only as useful as the insights we can glean from them. How might recent advances in interactive media and data visualization help illuminate and solve pertinent challenges in cancer research? Join in a series of virtual eventsto explore these questions and spark new collaborations between experts in cancer research, data visualization, user-experience, virtual/augmented reality, and game design/development.
There will be a series of four Micro Labs followed by a virtual poster session and 2-day Expo. Each Micro Lab starts with an inspiring conversation between thought leaders from the Cancer Moonshot and creative visualization experts followed by an opportunity to engage new colleagues from other fields in a fascinating discussion on the frontiers of cancer data visualization.
This series will feature HuBMAP HIVE-TC Harvard PI Nils Gehlenborg on Wednesday, September 2 at 1pm EDT. Link to Registration
Website Content Update Request
Members of the IEC are working to update the HuBMAP website to highlight information pertaining to data release. As data is continually released we welcome requests for content additions and or modifications to highlight information or features that may have recently been added to the data portal.
If you have a request, please send email to help@hubmapconsortium.org with the subject line: "Website Content Update" and accompanying text and or images.
Upcoming NIH Deadlines
Yearly Progress Reports (RPPRs) are due 6-8 weeks in advance of the end of the funding period. For your reference, here are the end dates for the different Components:
* RTIs - August 31, 2020
Viv: Multiscale Visualization of High-Resolution Multiplexed Tissue Data on the Web(Preprint)
A preprint from HuBMAP PIs Nils Gehlenborg, Katy Borner and Jeff Spraggins can be found at this link.
HIVE Demo Day Registration
Hosted by Indiana University
HIVE Demo Day (open to all consortium members): September 21-22, 2020
The agenda and general information can be foundhere.
Watch for Zoom links and a call for posters and/or recorded demos as the date of the event approaches.
The Hackathon focused on identification of cell types has been postponed until later this year. Stay tuned for me details.
I started a "Negativity Jar" to help keep me thinking positively while working at home. Each time I have a pessimistic thought I throw a dollar in.
It's currently half empty...
HIVE Infrastructure
Developers in need of HIVE infrastructure may request access through the PSC web form, foundhere.
Instructions for using HIVE infrastructure can now be found in the "Quick Links" section of the Collaboration Portal. A direct link to this documentation can be found here. Please report any issues or direct any questions to help@hubmapconsortium.org.
Content Suggestions
The IEC is seeking to collect information of general interest from individual members and groups and to share with the rest of the Consortium. Please submit content suggestions by emailing admin@hubmapconsortium.org.
Past Newsletters are available on the Collaboration Portal.
For comments, suggestions about how to improve the HuBMAP happenings, or questions about the consortium, please contact: help@hubmapconsortium.org
