Knee-d to bone up on cartilage cells? Check out the Image of the Week, which is of human cartilage from the knee-end of an adult femur stained with Safranin-O and imaged on a Zeiss Microscopy Axioscan microscope by the David Rowe lab at UConn. It’s the bee’s knees!
The next Cell Atlas Curation WG call will be held April 6 @ 10 AM EST. Zoom link. Running Notes.
Agenda 4/6/21:
Laura, Milen & Nils will lead a discussion to plan a workshop on high-level cross-atlas data integration. We will identify goals and key stakeholders who should be participating in the workshop.
Possible workshop goals:
Identify standardization needs to enable cell-level queries across atlases
Determine coordination process across atlas projects
Describe a roadmap for implementation of cross atlas queries
Challenges and Opportunities in Understanding Cellular Senescence and Senolytics (RFI)
The NIH has published three RFAs (RFA-RM-21-008; RFA-RM-21-009; RFA-RM-21-010) in January 2021 to develop 3D cellular senescence maps of healthy human tissues and to develop novel tools and technologies to address the role of senescent cells in human health and disease. While these human maps are the ultimate goal, much research in biomedicine is performed in mice, and extrapolation of the findings to human health requires a detailed understanding of both the similarities and the differences between these species. Ultimately, bidirectional crosstalk between findings in human and mouse, combined with the ability to test the effects of experimental perturbation in mice, will more fully inform the role of cellular senescence in health and disease and the consequences of interventions targeting this process. Therefore, as a follow up to the human RFAs, we would like to focus efforts on a similar and complementary goal in mice.
Enable Medicine (enablemedicine.com) is a new company out of Menlo Park, CA that runs CODEX-based image acquisition and analysis in their labs, and have a pipeline that performs single-cell segmentation, characterizes marker expression, and interprets cell-cell interaction maps. If you would be interested in speaking to them about their software platforms, please contact Archit Sheth-Shah
Save the Date(s):
HuBMAP Annual Meeting
This is a reminder to mark you calendars for May 19-21, 2021for the HuBMAP Annual Meeting. The meeting will be held virtually. Stay tuned for additional details.
HCA is also looking for reviewers to provide input on proposals for the Ancestry and Pediatrics Networks RFAs. If you're interested in reviewing, please contact Ellen Todres.
The next Human Cell Atlas General Meeting will be held June 28-30 and will take place virtually. To maximize participation from the global audience, main sessions will be scheduled between 9:00 AM - 1:00 PM EST each day. Recordings of talks will be available later for viewing on the event platform, as well as onYouTubeandBilibilichannels.
Please visit thewebsiteoremail for more information. Further details about HCAeventsare available.
This guide provides the process a data provider should follow when submitting data to HuBMAP for it to be displayed in the portal.
Since the goal is to continue enhancing the capabilities of the portal, this document will be versioned as changes are made. The HIVE recommends accessing the document via the link to ensure you are viewing the most up to date version.
Suggestions regarding the messaging within this document can be sent to the Help Desk.
Intra-Consortia Junior Investigator's Meeting: Seeking Planning Committee Members
Are you a graduate student or a postdoc? Are you interested in working with members from HTAN, CZI, as well as other HuBMAP members to create a junior investigator's meeting? Here is the advertisement for you!
We are soliciting three HuBMAP graduate students or postdocs to join the planning committee for an intra-consortia Junior Investigator's Meeting, which will virtually take place September 22-24.
If you are interested or have any questions, please email Elizabeth Neumann.
Reminders, Links to Resources, etc.
HuBMAP Haha
A reminder to anyone planning on proposing to their significant other this week:
Developers in need of HIVE infrastructure may request access through the PSC web form, found here.
Instructions for using HIVE infrastructure can now be found in the "Quick Links" section of the Collaboration Portal. A direct link to this documentation can be foundhere. Please report any issues or direct any questions tohelp@hubmapconsortium.org.
